Technical References

The tablet press feed-frame for monitoring tablet quality in a continuous manufacturing process

We look at the tablet press feed-frame as an optimum point for monitoring the quality of a tablet product made using a continuous manufacturing process.Pfizer/ GEA Continuous rig, PAT in a feedframe – Sentronic lollypop design, Feedframe set-up, Tablet press feedframe, Lubrication transition in the feed frame, Diffuse reflection, Optic probe interface - Sampling, Powder “micro-mixing” characterization, Sub dividing [...]

By |2019-11-20T14:26:26+01:00November 20th, 2019|Technical References|

New approaches to engineering sensors into pharmaceutical processing equipment

In pharmaceutical manufacturing, probes can rarely be inserted into a process “naked”. The dynamic nature of moving powders calls for a new approach to sampling. In-line applications of PAT require the engineering of a probe interface, for the optimum collection of spectral data. The effective sampling of the process, the amount of material needed to gain the best [...]

By |2019-11-20T14:15:20+01:00November 20th, 2019|Technical References|

Interfacing PAT Sensors with processing equipment

An adventure in sampling...We take a look at Pfizers Continuous Rig, the invention of a spider wheel interface, PAT interface for Continuous Mixing, diffuse reflection, optic probe interface - Sampling, powder “micro-mixing” characterization, sub dividing a tablet, development and refinement of the inline spider wheel, “Snow plough” wiper for side illumination probe from Sentronic, feeding, primary mixing and NIR, [...]

By |2019-11-20T14:32:11+01:00November 20th, 2019|Technical References|

NIR in Continuous Manufacture of Tablet Products

The importance of probe interfaces This paper will describe some of the efforts the Pharmaceutical the industry in general, are putting into the concepts of continuous manufacturing, married together with integrated analytics and advanced control systems. The combined technologies enable flexibility and rapid response to demand, and thus low inventory supply streams. The manufacturing plants occupy a small [...]

By |2019-09-10T17:32:56+01:00September 10th, 2019|Technical References|

The Feed Frame as an Ultimate Sample Interface for a Continuous Manufacturing System

The PAT community has over the years demonstrated that a spectroscopic system can be designed to collect representative spectral response data on powders. This can be achieved by momentarily stopping part of the flow, or isolating tablet cores holding them still and collecting spectral data of the surface, or collecting transmission data when radiation has passed through a [...]

By |2019-09-15T12:01:50+01:00September 9th, 2019|Technical References|