Over the last ten years, the path to effective development of PAT has evolved, driven by the advent of continuous manufacturing. The development and deployment of PAT used for pharmaceutical manufacturing has arrived at a point where application development has been miniaturized and streamlined.
The development of devices that can simulate the environment of a fiber optic probe in production equipment, using a small amount of material, in a laboratory environment has enabled the development of working models for the spectrometer using the minimum amount of material, separate from the large-scale manufacturing equipment. This capability has reduced the complexity and cost of developing PAT applications for a production environment.