In pharmaceutical manufacturing, probes can rarely be inserted into a process “naked”.
The dynamic nature of moving powders calls for a new approach to sampling.
In-line applications of PAT require the engineering of a probe interface, for the optimum collection of spectral data.
The effective sampling of the process, the amount of material needed to gain the best quality spectra, the need to “clean” the probe window between acquisition points, to ensure representative sampling, must all be considered, and their interactions understood.
The Optimum performance of a fiber optic probe depends on engineering solutions that deliver an optimum environment for spectral acquisition of representative samples.
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