The PAT community has over the years demonstrated that a spectroscopic system can be designed to collect representative spectral response data on powders. This can be achieved by momentarily stopping part of the flow, or isolating tablet cores holding them still and collecting spectral data of the surface, or collecting transmission data when radiation has passed through a tablet (see Figs. 41 and 42). These approaches have tended to minimize the noise contributions, by removing the disturbance contributions from powder or tablet movement…
Below is the full review paper of PAT strategies, managed by the University of Graz, Austria.
To jump to the section contributed by Stephen Hammond of ExpoPharma on; “The feed frame as an ultimate sample interface for a continuous manufacturing system”, either click here to open the Pdf on that page in a new window, or navigate to pages 698-703 (starting 32nd page of pdf) below.