We look at the tablet press feed-frame as an optimum point for monitoring the quality of a tablet product made using a continuous manufacturing process.

Pfizer/ GEA Continuous rig, PAT in a feedframe – Sentronic lollypop design, Feedframe set-up, Tablet press feedframe, Lubrication transition in the feed frame, Diffuse reflection, Optic probe interface – Sampling, Powder “micro-mixing” characterization, Sub dividing a tablet, How much sample is scanned in the feedframe, PAT5 – Feed Frame –Low Dose Product, Plot of NIR response at two throughputs Vs HPLC of Cores, PCMM In-line Development, and Tech Batch – Steady state run.

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